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Lymphomatoid Papulosis Followed by Ki‐1 Positive Anaplastic Large Cell Lymphoma: Proliferation of a Common T‐Cell Clone
Author(s) -
Amagai Masayuki,
Kawakubo Yo,
Tsuyuki Akira,
Harada Reiko
Publication year - 1995
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1995.tb03913.x
Subject(s) - lymphomatoid papulosis , anaplastic large cell lymphoma , clone (java method) , lymphoma , medicine , nodule (geology) , papule , pathology , immunohistochemistry , biology , cd30 , lesion , gene , paleontology , biochemistry
We report a case of lymphomatoid papulosis (LyP) followed by Ki‐1 positive anaplastic large cell lymphoma (LCL). A 33‐year‐old man developed subcutaneous nodules in the left inguinal region and the left thigh after a seven‐year‐history of self‐healing papulonecrotic lesions of LyP. Histological and immunohistochemical examination of the subcutaneous nodules revealed LCL. DNA was isolated from a nodule of the initial stage of LyP in 1988, a subcutaneous nodule of LCL in 1993, and a papule of LyP in 1993 which appeared after chemotherapy for LCL. T cell receptor gene rearrangement analysis demonstrated an identical rearranged pattern in all the three specimens, indicating that a common T cell clone proliferated throughout the course in both the LyP and LCL lesions.