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Low Expression of Adhesion Molecules in a Case of Cutaneous T‐cell Lymphoma
Author(s) -
Miyazawa Megumi,
Takahashi Sanami,
Kawaguchi Hiroshi,
Nagatani Tetsuo,
Higuchi Mitsuhiro,
Matsuzaki Toshiko,
Iemoto Gaijiro,
Kim ShuTaku,
Baba Naoko,
Miyamoto Hideaki,
Nakajima Hiroshi
Publication year - 1995
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1995.tb03894.x
Subject(s) - mycosis fungoides , pathology , cell adhesion molecule , dermis , cutaneous t cell lymphoma , lymphoma , biopsy , medicine , infiltration (hvac) , reticular dermis , antigen , immunology , physics , thermodynamics
A case of cutaneous T‐cell lymphoma (CTCL) with low expression of the adhesion molecules lymphocyte function‐associated antigen‐1 (LFA‐1), intercellular adhesion molecule‐1 (ICAM‐1), and very late antigen‐4 (VLA‐4) is described. The patient was a 90‐year‐old man with red round homogeneous tumors on his scalp, trunk, and extremities. He had no history of definite erythema or plaque stage. A biopsy sample taken from a tumor revealed massive infiltration of atypical lymphocytes in the reticular dermis and subcutis with a definite clear zone. The atypical lymphocytes were medium‐sized with slightly convoluted nuclei. Immunohistochemically, the infiltrates showed the phenotype of so‐called memory T cells. On the basis of these features, the case was diagnosed as CTCL. Expression of LFA‐1, ICAM‐1 and VLA‐4 on the infiltrates was 9%, 13% and 11%, respectively, which is much lower than that in classic mycosis fungoides. This finding suggests that loss of these adhesion molecules may contribute to loss of epidermotropism in the advanced stage of CTCL.