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Cytokine Profile of Tumor Cells in Mycosis Fungoides: Successful Treatment with Intra‐lesional Interferon‐ γ Combined with Chemotherapy
Author(s) -
Yamamoto Toshiyuki,
Sasaki Go,
Sato Takahiro,
Katayama Ichiro,
Nishioka Kiyoshi
Publication year - 1995
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1995.tb03892.x
Subject(s) - mycosis fungoides , interferon , cytokine , chemotherapy , medicine , reverse transcriptase , pathology , immunotherapy , interferon gamma , cancer research , messenger rna , immunology , polymerase chain reaction , lymphoma , biology , immune system , gene , biochemistry
Two cases of mycosis fungoides (MF) in the tumor stage were treated with intra‐lesional interferon‐ γ (IFN‐ γ ) therapy. After systemic chemotherapy, intra‐lesional recombinant interferon‐ γ was applied to the residual tumors. Intra‐lesional IFN‐ γ was sufficiently effective in the treatment of MF tumors, especially small‐sized ones. Reverse transcriptase polymerase chain reaction (RT‐PCR) analysis of messenger RNA expression of cytokines commonly detected interleukin‐6 (IL‐6) and IFN‐ γ in the tumor cells before intra‐lesional IFN‐ γ . However, in our study, tumor cells in these cases did not exhibit the definitive cytokine patterns of Th1 or Th2.