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Successful Treatment of Severe Arthralgia Associated with Palmoplantar Pustulosis with Low‐Dose Oral Cyclosporine A
Author(s) -
Yamamoto Toshiyuki,
Kimura Kyouko,
Katayama Ichiro,
Nishioka Kiyoshi
Publication year - 1995
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1995.tb03435.x
Subject(s) - palmoplantar pustulosis , medicine , desquamation , erythema , dermatology , gastroenterology , psoriasis
Two patients with severe arthralgia associated with palmoplantar pustulosis (PPP) were treated with oral cyclosporine A (CsA). Clinical efficacy was assessed on a 0–4 point scale for erythema, desquamation, infiltration, and pustulation, and on a 0–3 point pain scale. Skin lesions and arthralgia improved within twelve weeks with low dose CsA ranging from 2.1 to 2.2 mg/kg/day. High levels of plasma interleukin‐6 (IL‐6) were reduced to the normal range.