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Correlation of Lesional Skin Corneometry Values with Serum E‐Selectin Levels and Disease Severity in Patients Affected by Plaque‐type Psoriasis: Recovery after Effective Therapy
Author(s) -
Carducci Massimo,
Mussi Anna,
Bonifati Claudio,
Tomaselli Roberta,
Onorati Maria Teresa,
Trento Elisabetta,
Ameglio Franco
Publication year - 1995
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1995.tb03427.x
Subject(s) - medicine , plaque psoriasis , psoriasis , psoriasis area and severity index , gastroenterology , correlation , lesion , severity of illness , desquamation , surgery , dermatology , geometry , mathematics
Abstract Ten subjects with plaque‐type psoriasis (5 females, 5 males, median age 47, range 20–71 years, median psoriasis area and severity index [PASI] score=15.5, range 8.1–23.0) were observed before (week 0) and at the second and sixth week after starting treatment (PASI=10.5, range 7.8–14.6; PASI=8.5, range 1.6–11.6, respectively). At each of these times, the patients were evaluated for both lesional and unlesional skin corneometry and serum E‐selectin values, previously shown to be increased in psoriatic subjects. At time 0, both the corneometry and the E‐selectin values were significantly correlated with the PASI, infiltration and desquamation scores. As expected, the corneometry was statistically higher in the unlesional than in the lesional areas (p<0.001). After therapy, the lesion improvement was related both to the PASI scores and E‐selectin level decreases (from median levels of 15.5 to 8.5 and from 18 to 13.2 ng/ml, respectively, p<0.05) as well as to the corneometric level increases (from a median value of 34.5 to 42, p<0.05). Considering the data obtained at all of these times, significant correlations were found between the PASI scores, lesional skin corneometry and serum E‐selectin levels. In conclusion, lesional corneometry seems to represent an objective alternative method for reliably monitoring psoriatic patients.