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The Correlation of Kampo Formulations and Their Ingredients on Anti‐bacterial Activities against Propionibacterium acnes
Author(s) -
Higaki Shuichi,
Hasegawa Yoshinori,
Morohashi Masaaki,
Takayoshi Yamagishi
Publication year - 1995
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1995.tb03332.x
Subject(s) - kampo , propionibacterium acnes , traditional medicine , medicine , active ingredient , pharmacology , dermatology , pathology , alternative medicine , acne
The correlation between the susceptibilies of Propionibacterium acnes strains to two Kampo formulations and these to their ingredients (Kampo crude drugs) was examined. Two out of 19 Kampo crude drugs, Coptidis Rhizoma (CR) and Phellodendri Cortex (PC), inhibited the growth of P. acnes significantly. The patterns of distribution of the minimal inhibitory concentrations of Keigai‐rengyo‐to (KRT) and of Seijo‐bofu‐to (SBT) were almost the same as those of the Kampo crude drugs, except CR and PC. Furthermore, no correlations between MIC S of Kampo formulations and those of their ingredients against P. acnes were found. This might be due to mutual inhibition or to differences in anti‐bacterial mechanisms between the two Kampo formulations and their ingredients. The Kampo formulations, composed of CR, PC and a few other kinds of Kampo crude drugs, might be more susceptible against P. acnes , since higher concentrations of the effective ingredients can be achieved.