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Hyperthermic Isolated Limb Perfusion with Intra‐Arterial Administration of Carboplatin and/or Interferon‐β for the Treatment of Malignant Melanoma of the Leg
Author(s) -
Nakayama Juichiro,
Takeuchi Minora,
Mayumi Hisanori,
Nagae Shonosuke,
Matsuda Kazuhisa,
Yasui Hisataka,
Takahashi Shosuke,
Hori Yoshiaki
Publication year - 1994
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1994.tb03311.x
Subject(s) - medicine , perfusion , melanoma , carboplatin , chemotherapy , concomitant , stage (stratigraphy) , surgery , cancer research , cisplatin , paleontology , biology
Our experiences of hyperthermic isolated limb perfusion with administration of carboplatin, interferon‐β or a combination of both are reported. Administration of high doses of these reagents was well tolerated by patients with melanoma without severe complications after the treatment. A total of 8 patients underwent this therapeutic modality. Remarkable clinical improvement was seen in the first patient, who was in Stage III at the time of the perfusion. Histopathological findings indicated severe damage to the melanoma cells after the operation. Prophylactic hyperthermic perfusion was performed in 6 other patients with Stage II–III melanoma of the lower limb. None of them have shown any signs of recurrence 1–10 months later. The activities of natural killer cells or T lymphocytes appeared to be increased when the perfusion was carried out with concomitant administration of both carboplatin and interferon‐β. These results suggest that hyperthermic isolated limb perfusion with carboplatin and/or interferon β administration is effective in patients with advanced stage melanoma.