Premium
Novel Experimental Approaches to Melanoma Diagnosis and Therapy
Author(s) -
Hearing Vincent J.,
Gersten Douglas M.,
Shrayer David,
Law Lloyd W.
Publication year - 1994
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1994.tb03302.x
Subject(s) - melanoma , metastatic melanoma , monoclonal antibody , medicine , concomitant , immune system , cancer research , monoclonal antibody therapy , immunology , immunotherapy , antibody , oncology
We have investigated the potential use of immune therapies on the growth of melanoma metastases in a new animal model that more closely approximates the clinical situation. We have found that significant benefits towards decreased metastatic growth and subsequent animal survival can be achieved by treatment of tumor‐bearing mice with melanoma‐specific monoclonal antibodies or alternatively, with various types of monovalent or polyvalent vaccines. The beneficial effects of those vaccines can be significantly enhanced by concomitant interleukin‐2 therapy.