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Oral Minocycline Improved Keratosis Follicularis Squamosa (Dohi) and Related Disorder: Bacterial Factors are Possibly Involved in Abberant Keratinization
Author(s) -
Katayama Ichiro,
Yokozeki Hiroo,
Nishioka Kiyoshi
Publication year - 1994
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1994.tb01802.x
Subject(s) - minocycline , dermatology , keratosis , medicine , biology , microbiology and biotechnology , antibiotics
Three cases of keratosis follicularis squamosa (Dohi) and one case of papillomatose confluente et reticulee were successfully treated with oral minocycline (50‐100 mg/day). The clinical effect first appeared at 2 weeks after the initiation of therapy and no recurrence was observed for more than 3 months without minocycline. Gram positive cocci were demonstrated inside the hair follicle and horny layers in all 4 case. Minocycline might modulate abberant keratinization through its bactericidal effects in these keratinizing disorders.