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Immunohistochemical Distribution of CD44 and Desmoplakin I & II in Hailey‐Hailey's Disease and Darier's Disease
Author(s) -
Harada Masashi,
Hashimoto Ken,
Fujiwara Keiko
Publication year - 1994
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1994.tb01760.x
Subject(s) - desmoplakin , darier's disease , pathology , hailey–hailey disease , desmosome , cd44 , medicine , biology , cell , disease , genetics
The cell‐surface glycoprotein CD44 is found on a wide variety of cells including epidermal cells. It is involved in cell to cell adhesion. Desmoplakin I & II are important components of the attachment plaque of desmosomes. In this study, we compared the distribution patterns of anti‐CD44 and anti‐desmoplakin I & II in Hailey‐Hailey's disease and Darier's disease. In the normal skin, anti‐CD44 stained the entire periphery of epidermal keratinocytes while anti‐desmoplakin I & II produced dotted staining patterns along the periphery of epidermal keratinocytes. In Hailey‐Hailey's disease and Darier's disease, the staining pattern of anti‐CD44 on acantholized keratinocytes did not change, but anti‐desmoplakin I & II lost their peripheral, dotted patterns and stained diffusely in the cytoplasm in most acantholytic cells. These results suggest that, in Hailey‐Hailey's disease and Darier's disease, CD44 may be intact even in acantholytic cells but abnormalities of desmoplakin exist in such cells.