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Langerhans Cell Histiocytosis Presenting as a Varicelliform Eruption over the Entire Skin
Author(s) -
Johno Masayoshi,
Oishi Munashi,
Kohmaru Masahiro,
Yoshimura Kohji,
Ono Tomomichi
Publication year - 1994
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1994.tb01721.x
Subject(s) - birbeck granules , langerhans cell histiocytosis , medicine , pathology , histiocytosis , histopathological examination , dermatology , diarrhea , langerhans cell , immunology , disease , antigen
A boy with skin eruptions resembling varicella and specific for Langerhans cell histiocytosis (LCH) is reported. At his initial visit when he was four months old, vesiculopustular lesions were present over the entire body; these had first appeared on the third day post partus. Histopathological, immunohistochemical, and electron microscopical examination confirmed the Langerhans cell phenotype and Birbeck granules in the responsible cells. He also had hydronephrosis, recurrent fever, and cutaneous bacterial infections. His parents refused further medical treatment and he died of diarrhea with cachexia about two years later. LCH may present diagnostic difficulties by manifesting as a skin eruption which resembles varicella.