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Secretion of IL‐2, IL‐4, and IFN‐γ for Dust Mite Antigens in a Patient with Atopic Dermatitis
Author(s) -
Kubota Yumiko,
Koga Tetsuya,
Imayama Shuhei,
Hori Yoshiaki
Publication year - 1993
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1993.tb03836.x
Subject(s) - peripheral blood mononuclear cell , atopic dermatitis , immunology , antigen , interleukin 4 , incubation , secretion , house dust mite , interleukin , medicine , allergy , peripheral blood , interferon gamma , cytokine , chemistry , allergen , in vitro , endocrinology , biochemistry
In a 21‐year‐old female with severe atopic dermatitis, the secretion of interleukin‐2 (IL‐2), interleukin‐4 (IL‐4), and interferon‐γ (IFN‐γ) by her peripheral blood mononuclear cells (PBMC) was measured after incubation with/without antigens extracted from Dermatophagoides pteronyssinus (Dp), to which the patient had developed a positive patch‐test reaction. Incubation with Dp antigen produced marked secretion of IL‐2 and IFN‐γ, but not IL‐4. This may suggest that Dp‐specific T lymphocytes present in the circulating blood cells are capable of producing IL‐2 and IFN‐γ, which may be relevant to the delayed‐type allergic reaction occurring in the skin lesion.