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Erythroderma, Hair Loss, and Sinus Histiocytosis with Massive Lymphadenopathy in a XYY‐Male
Author(s) -
Tsukahara Tetsuya,
Horiuchi Yasuhiro,
Ohkawa Tsukasa,
Masuzawa Mikio,
Nishiyama Shigeo,
Ohida Makiko
Publication year - 1993
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1993.tb03829.x
Subject(s) - histiocyte , erythroderma , sinus histiocytosis with massive lymphadenopathy , pathology , scalp , medicine , sinus (botany) , giant cell , dermatology , biology , rosai–dorfman disease , botany , genus
This paper presents a case of sinus histiocytosis with massive lymphadenopathy (SHML) presenting as erythroderma in an XYY‐male aged 27. The patient had little or no scalp, axillary, or pubic hair. Histologically, lymph nodes indicated dilatation of the sinuses with proliferation of benign‐appearing histiocytes possessing abundant clear cytoplasm, admixed with giant cells and pericapsular fibrosis. Infiltrating histiocytes in the lymph nodes were OKM‐1 (CD11b) positive, which is characteristic of monocyte‐granulocyte lineages. In the present case, the abnormal presence of erythroderma, hair loss, SHML, and a chromosomal abnormality, XYY, were thought to be incidental features.