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Electron‐microscopic Observation of a Human Epidermal Langerhans Cell in Mitosis
Author(s) -
Kanitakis Jean,
Hoyo Eduardo,
Perrin Claude,
Schmitt Daniel
Publication year - 1993
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1993.tb03826.x
Subject(s) - epidermis (zoology) , mitosis , langerhans cell , microbiology and biotechnology , biology , cell , human skin , pathology , immunology , anatomy , medicine , antigen , biochemistry , genetics
Langerhans cells are dendritic cells of the epidermis originating from bone marrow precursors which may exceptionally undergo mitosis within the skin. We report herein an electron‐microscopic observation of a dividing LC within a seemingly hyperproliferative human epidermis. This observation further underlines the self‐reproducing capacity of LC in situ and suggests that LC may respond to the same mitogenic stimuli as keratinocytes.