Premium
Association of Generalized Granuloma Annulare with Autoantibodies
Author(s) -
Tada Joji,
Seno Akemi,
Ueda Masumi,
Arata Jirô,
Nagao Yo
Publication year - 1993
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1993.tb01394.x
Subject(s) - granuloma annulare , autoantibody , histiocyte , giant cell , pathology , medicine , anti nuclear antibody , pathogenesis , immune system , rheumatoid factor , granuloma , antibody , immunology
Granuloma annulare is a degenerative disease of the skin histopathologically characterized by focal degeneration of collagen with a surrounding infiltrate of lymphoid cells, histiocytic cells, and multinucleated giant cells. Immunological abnormalities such as delayed‐type hypersensitivity and vasculitic origin are suspected in the pathogenesis. We describe three patients with generalized granuloma annulare, in whom autoantibodies, including antinuclear antibody, antithyroid stimulating hormone receptor antibody, and immune complex, were detected.