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Increased Incidence of Antismooth Muscle Antibody in Korean Vitiligo Patients
Author(s) -
Hann Seung Kyung,
Im Sungbin,
Kim Hyung Il,
Kim HyonSuk,
Lee Yung Jae,
Park YoonKee
Publication year - 1993
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1993.tb01363.x
Subject(s) - vitiligo , medicine , autoantibody , anti nuclear antibody , incidence (geometry) , antibody , thyroglobulin , diabetes mellitus , immunology , dermatology , gastroenterology , pathology , endocrinology , physics , optics
To evaluate the incidence of autoimmune disorders and organ‐specific autoantibodies in Korean vitiligo patients, antibodies to nuclear, mitochondrial, smooth muscle, gastric parietal cell, thyroglobulin, and microsomal antigens were screened in 226 vitiligo patients and 120 controls. Of the 226 vitiligo patients, three (1.3%) had thyrotoxicosis and two (0.8%) had diabetes mellitus. The vitiligo patients had an increased incidence of antinuclear (12.4%), antimicrosomal (7.1%), and antismooth muscle antibodies (25.7%). The increased incidence of antismooth muscle antibody was correlated with early onset (less than 15 years), a positive family history of vitiligo, and long duration of vitiligo. These results support an autoimmune origin of vitiligo and suggest that the high incidence of antismooth muscle antibody is a distinctive feature of laboratory findings in Korean vitiligo patients.