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Progressive Systemic Sclerosis Preceded by Malignant Lymphoma
Author(s) -
Yamamoto Toshiyuki,
Furuse Yoshiro,
Nishioka Kiyoshi
Publication year - 1993
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1993.tb01355.x
Subject(s) - medicine , lymphoma , malignant lymphoma , anti nuclear antibody , pathology , antibody , immunology , autoantibody
We report a patient who suffered from progressive systemic sclerosis (PSS) two years after she showed evidence of malignant lymphoma of the jejunum. Surgical resection of the tumor mass and VEMP regimen were successful; the patient was in remission but died of acute respiratory failure five years later. Although several reports have reported malignant lymphoma associated with PSS, lymphoma antecedent to PSS is rarely seen. Immune abnormalities including a high titer of antinuclear factor and positive anti‐RNP antibodies were suspected to be associated with the development of PSS in our case.