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A Case of Adamantinoid Basal Cell Epithelioma
Author(s) -
Mohri Shinobu,
Andoh Shin'ichiro,
Matsushitay Kazuhiko,
Konishi Yoshiro
Publication year - 1993
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1993.tb01327.x
Subject(s) - vimentin , pathology , desmin , carcinoembryonic antigen , immunohistochemistry , stroma , biology , dermis , antigen , basal lamina , anatomy , medicine , ultrastructure , cancer , immunology , genetics
Abstract A 56‐year‐old woman visited the clinic of dermatology, Yokohama Sakae Kyosai Hospital in May of 1992 with a 5‐year history of a blue‐gray lesion on her left cheek which had enlarged asymptomatically. The tumor was excised with Z plasty closure. Histopathologically, a loosely encapsulated tumor was situated in the upper to deep dermis. At the periphery of the tumor, there were typical solid basal cell epithelioma (BCE) nests, but within the majority of lobules, intercellular spaces were widened and cells were connected by stellate appendages. Mucoid material filled the spaces and the cells at the periphery palisaded. Histochemical study revealed that the mucoid substance contained hyaluronic acid. An immunohistochemical study was performed using peroxidase antiperoxidase (PAP) method. The antibodies used were anti‐epithelial membrane antigen (EMA), anti‐carcinoembryonic antigen (CEA), anti‐S‐100 protein, anti‐neurofilament, anti‐vimentin, anti‐desmin, anti‐BRST‐1, and anti‐BRST‐2. The tumor cells and stroma expressed none of these antigens. The tumor was diagnosed as an adamantinoid BCE.