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Vitiligo, Rheumatoid Arthritis and Pernicious Anemia
Author(s) -
Abraham Zeev,
Rozenbaum Michael,
Glück Zahava,
Feuerman Eleasar J.,
Lahat Nitza,
Kinarty Amalia
Publication year - 1993
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1993.tb01310.x
Subject(s) - pernicious anemia , vitiligo , medicine , rheumatoid arthritis , dermatology , anemia , immunology
A patient with a 46‐year history of vitiligo who also presented rheumatoid arthritis and pernicious anemia is described. Meticulous physical examination excluded further systemic or cutaneous involvement. The immunological workup revealed a low CD 4 cell percentage with T cells mostly composed of CD 8 cells, a discrepancy between the high percentage of cumulative CD 4 + CD 8 cells and the measured CD 3 proportions, very low NK cytotoxicity toward K 562 cells, and almost negligible responses to PHA, Con A and PWM mitogens. The results point to severe T and NK cell functional defects. The pathogenetic significance of these data is discussed.