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Analysis of 70 KD Heat Shock Protein (HSP70) Expression in the Lesional Skin of Lupus Erythematosus (LE) and LE Related Diseases
Author(s) -
Ghoreishi Mehran,
Katayama Ichiro,
Yokozeki Hiroo,
Nishioka Kiyoshi
Publication year - 1993
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1993.tb01307.x
Subject(s) - hsp70 , heat shock protein , systemic lupus erythematosus , shock (circulatory) , medicine , lupus erythematosus , protein expression , immunology , dermatology , pathology , chemistry , antibody , biochemistry , disease , gene
Biopsied specimens from skin lesions of SLE were studied for expression of 70 KD heat shock protein (HSP70). The pattern of HSP70 expression in SLE was diffuse in whole epidermis, hair follicles, and sweat gland cells and rather more intense than that in other control groups or normal skin. No significant differences in HSP70 expression were observed between sun‐exposed and protected areas of SLE skin lesions. Unlike SLE, reduced or no expression of HSP70 was observed in skin lesions of DLE. In tissue culture, UVB radiation in vitro induced relatively intense expression of HSP70 in the nuclear area of keratinocytes. A few γδ T cell receptor positive cells which might respond to HSP70 expressing cells were detected in the basal layer of skin lesions of diseases. These studies suggest that abberant expression of HSP70 in skin lesions of SLE might contribute to both skin lesions and antibody formation in SLE.