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An AIDS Patient with Atopic Dermatitis‐like Eruption Responsive to Systemic Anti‐fungal Treatment
Author(s) -
Hoashi Mariko,
Imayama Shuhei,
Hori Yoshiaki,
Kashiwagi Seiichiro
Publication year - 1992
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1992.tb03815.x
Subject(s) - medicine , atopic dermatitis , antihistamine , dermatology , candida albicans , immunology , genetics , biology
Patients with the acquired immunodeficiency syndrome (AIDS) often develop unusual skin complications. We describe a case of a 58‐year‐old man with AIDS who had a history of multiple transfusions with anti‐hemophilic factor A. He developed papulovesicular and lichenified skin lesions on his head, face, neck and the extensor aspects of his extremities accompanied by severe pruritus. Atopic dermatitis was suspected; however, intensive treatment with a potent topical corticosteroid and a systemic antihistamine failed. In addition to the decreased subset of CD4‐positive lymphocytes characteristic of AIDS, this patient showed an elevated level of serum IgE particularly specific for Candida albicans , probably because he had a chronic candidial infection of the digestive tract. Oral administration of anti‐fungal agents Diflucan® and Fungizone® produced almost complete relief from the atopic dermatitis‐like skin disease within 2 weeks.