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Expression of Neuron‐specific Enolase Immunoreactivity by Cutaneous and Extracutaneous Langerhans‐cell Histiocytoses (“X”)
Author(s) -
RocaMiralles Mercedes,
Kanitakis Jean,
BéjuiThivolet Françoise,
Schmitt Daniel,
CastelsRodellas Antonio,
Thivolet Jean
Publication year - 1992
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1992.tb03810.x
Subject(s) - enolase , pathology , langerhans cell histiocytosis , eosinophilic granuloma , immunohistochemistry , s100 protein , histiocytosis , langerhans cell , medicine , biology , antigen , disease , immunology
The immunohistochemical expression of Neuron‐Specific Enolase (NSE) and of S100 protein was studied in 10 cases of cutaneous and 19 cases of extracutaneous Langerhans cell histiocytoses (LCH), including acute/proliferative forms (cutaneous Letterer‐Siwe disease) and chronic/granulomatous forms (eosinophilic granuloma, Hand‐Schüller‐Christian disease). Of the LCH cases, 18 (62%) exhibited detectable NSE‐immunoreactivity as compared to 82.8% for S100. NSE expression was found more frequently and intensely within acute (as compared to chronic) forms of LCH. This result lends further support to the cellular unicity of LCH, but also suggests some degree of heterogeneity among LCH cells. It can be speculated that NSE‐expression is correlated with the proliferation/activation state of (abnormal) Langerhans cells.