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Dysregulated Expression of Cellular Adhesion Molecules in Autoimmune‐prone Mice
Author(s) -
Wang Weila,
Kobayashi Seiichi,
Uede Toshimitsu
Publication year - 1992
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1992.tb03792.x
Subject(s) - lymph , high endothelial venules , cell adhesion molecule , lymph node stromal cell , cd44 , antigen , lymphocyte homing receptor , lymphocyte , immunology , lymph node , biology , cell adhesion , cell , chemistry , pathology , microbiology and biotechnology , medicine , genetics
The expression of various cell adhesion molecules on lymphocytes and endothelial cells was examined. The strong expression of CD44 antigen on abnormal double negative T cells of lymph nodes was characteristic in MRL‐lpr mice. The accumulation of abnormal double negative T cells in swelling lymph nodes was also predominant in MRL‐lpr mice; this may result from augmented binding of lymphocytes to endothelial cell surfaces of lymph nodes, possibly due to the failure of Mel‐14 antigen shedding from abnormal lymphocyte cell surface. The expression of VCAM‐1 antigen was detected in endothelial cell surface of lymph nodes in MRL‐lpr mice, which also explains the accumulation of lymphocytes in lymph nodes. However, the expression of VLA‐4 antigen on lymphocytes which interact with VCAM‐1 on endothelial cells was not significantly different between MRL‐lpr and MRL‐+ mice.