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Inactivation of Keratin Genes by Gene Targeting: A Perspective
Author(s) -
Oshima Robert G.,
Baribault Hélène
Publication year - 1992
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1992.tb03781.x
Subject(s) - gene , gene technology , function (biology) , perspective (graphical) , computational biology , biology , keratin , genetic engineering , genetics , microbiology and biotechnology , computer science , artificial intelligence
Recent technological advances in experimental molecular genetics have provided an opportunity for determining the function of any gene including those which are important in different epithelia. This report summarizes some recent results of experiments utilizing gene targeting technology to determine the function of intermediate filaments and emphasizes both the problems and the potential of applying this technology to problems in dermatology.