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The Interaction between Langerhans Cells and CD4 + T Cells
Author(s) -
Hauser Conrad
Publication year - 1992
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1992.tb03768.x
Subject(s) - antigen presenting cell , cd1 , immune system , antigen , immunology , interleukin 21 , interleukin 12 , biology , langerhans cell , microbiology and biotechnology , t cell , cd40 , interleukin 3 , cytotoxic t cell , in vitro , biochemistry
The human skin is increasingly exposed to haptens and environmental protein antigens. Because Langerhans cells represent the outermost network of MHC class II + antigen presenting cells in mammalians, we investigated their interaction with CD4 + T cells. Hapten‐modified Langerhans cells induced proliferation and IL‐2 production in naive resting CD4 + T cells. T cells activated in this manner and subsequently cultured with IL‐2 mediated contact sensitivity in vivo and produced IL‐2 but no IL‐4 upon restimulation in vitro . Thus they corresponded to Th1 cells. Repeated stimulation with Langerhans cells induced a modulation of the lymphokine pattern: IL‐2‐ and IL‐4‐producing Th0‐like cells were identified after 3 to 4 rounds of restimulation; after >5 rounds, Th2‐like cells with an IL‐4 + IL‐2 − pattern and the capacity for inducing IgE synthesis in B cells was identified. Th2 cells were also recently found to mediate inflammatory tissue lesions containing a cellular infiltrate. This demonstrates that Langerhans cells may activate resting CD4 + T cells, Th1‐, Th0‐ and Th2‐like cells. It further shows that Langerhans cells may promote the differentiation of postthymic CD4 + T cells into subsets with distinct immune functions: Th1 cells which have the potential to mediate inflammatory reactions such as allergic contact sensitivity and Th2 cells which may be responsible for abnormalities associated with atopic dermatis, such as elevated IgE and inflammatory skin lesions containing a cellular infiltrate.