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The Role of Growth Factor in Wound Healing
Author(s) -
Higashiyama Mari,
Hashimoto Koji,
Takada Akiyoshi,
Fujita Kazuhiko,
Kido Katsunobu,
Yoshikawa Kunihiko
Publication year - 1992
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1992.tb03758.x
Subject(s) - wound healing , epidermis (zoology) , immunohistochemistry , regeneration (biology) , pathology , medicine , anatomy , biology , surgery , microbiology and biotechnology
A pig wound healing model was developed to study the morphological processes involved in incisional and excisional wound healing, the immunohistochemical localization of TGF‐ α in wound healing, and the latter's relevance. In incisional wounds, a few layers of epidermis were regenerated after only 32 hours. In contrast, several layers of epidermis were regenerated on day 7 in excisional wounds. In general, the incisional wound model is useful for evaluating tensile strength, while the excisional wound model is suitable for evaluating epidermal regeneration. Immunohistochemical study showed that keratinocytes migrating from wound edges expressed TGF‐ α very faintly, while TGF‐ α was present prominently in the upper several layers of the epidermis adjacent to the wound, which resembled normal epidermis and showed no changes during the wound healing process.