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The Effects of Basic Fibroblast Growth Factor and Doxorubicin on Cultured Human Skin Fibroblasts: Relevance to Wound Healing
Author(s) -
Sasaki Tetsuo
Publication year - 1992
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1992.tb03755.x
Subject(s) - wound healing , fibroblast , collagenase , doxorubicin , basic fibroblast growth factor , in vitro , human skin , cancer research , growth factor , pharmacology , chemistry , medicine , microbiology and biotechnology , biology , immunology , chemotherapy , biochemistry , enzyme , receptor , genetics
The effects of basic fibroblast growth factor (bFGF) and doxorubicin on cultured human skin fibroblasts were examined in order to determine their relevance to wound healing. bFGF is shown to stimulate fibroblast collagenase production per cell, and this effect in vitro seems to be one explanation for its efficacy in wound healing. Doxorubicin inhibited not only fibroblast proliferation but also collagen production by inactivating prolyl hydroxylase. This result may explain the reduced wound healing in patients undergoing treatment with doxorubicin. These studies indicate the importance of assessing the effects of growth factors on matrix metabolism in order to understand their roles in wound healing.