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A Case of Subepidermal Blister Disease Associated with Autoantibody against 450 kD Protein
Author(s) -
Fujiwara Sakuhei,
Shinkai Hiroshi,
Takayasu Susumu,
Owaribe Katsushi,
Tsukita Shoichiro,
Kageshita Toshiro
Publication year - 1992
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1992.tb03738.x
Subject(s) - bullous pemphigoid , immunofluorescence , blisters , basement membrane , autoantibody , direct fluorescent antibody , cyclophosphamide , antigen , medicine , pemphigoid , dermatology , pathology , trunk , chemistry , antibody , immunology , biology , chemotherapy , ecology
We report a case of subepidermal blister disease with eruptions distributed on the trunk and extremities. The blisters regressed after administration of corticosteroid and cyclophosphamide. An immunoblot analysis revealed that the patient's serum reacted exclusively with a 450‐kD epidermal polypeptide. It did not react with a 230‐kD or a 180‐kD bullous pemphigoid antigen. The immunofluorescence study showed the patient's serum reacted with the basement membrane zone of human skin.