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A Case of Cytophagic Histiocytic Panniculitis with Sicca Symptoms and Lupus Nephritis
Author(s) -
Tsukahara Tetsuya,
Fujioka Akira,
Horiuchi Yasuhiro,
Eto Hikaru,
Nishiyama Shigeo,
Akaboshi Tohoru,
Kokubo Tohoru
Publication year - 1992
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1992.tb03730.x
Subject(s) - histiocyte , medicine , pathology , panniculitis , lupus nephritis , sicca syndrome , cd68 , cd11c , dermatology , chemistry , immunohistochemistry , disease , biochemistry , gene , phenotype
A 48‐year‐old Japanese woman presented with many subcutaneous nodules. The skin was purplish in color and tender; the nodules were scattered over the entire surface. Histological findings of biopsy specimens from the nodules indicated septal panniculitis comprised of histiocyte and/or macrophage infiltrates, often with erythro‐ and/or leukophagocytosis. Phagocytic cells were OKM1 (CD11b), MT1 (CD43), LeuM3 (CD14), and histiocyte antigen positive, indicating the presence of histiocytes and/or macrophages. The patient had sicca symptoms, positive homogenous, speckled pattern ANA (×320), and diffuse proliferative lupus nephritis.