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Aneuploidy in Chronic Actinic Dermatitis
Author(s) -
Bingsen Qiu,
Kanghuang Liao,
Hongzhen Ni
Publication year - 1992
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1992.tb03726.x
Subject(s) - aneuploidy , flow cytometry , pathology , biopsy , skin biopsy , biology , medicine , microbiology and biotechnology , chromosome , biochemistry , gene
DNA content and cell cycle distributions in paraffin‐embedded blocks of 19 skin biopsy specimens from 17 patients with chronic actinic dermatitis (CAD) [8 patients showed typical actinic reticuloid (AR)] were estimated by DNA cytometry. Sixty‐three percent (12/19) of the skin specimens showed aneuploidy. In the 4 cases with the highest DNA indices (DI), ranging from 1.65 to 1.88 (mean: 1.84), the proportions of cells in S and G 2 /M phases were increased, ranging from 15–48% (mean: 20%) and from 64–76% (mean: 70.5%), respectively. In 8 cases with DI ranging from 1.15–1.75 (mean: 1.5), the proportion of cells in S‐phase was also increased, ranging from 30–90% (mean: 81.1%). Histologically, it seems likely that the relatively high frequency of aneuploidy, DI, and proportions of cells in the S and/or G 2 /M phases were not proportional to epidermal or vascular endothelial hyperplasia, but they might be related to dermal lymphoid infiltration.