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Immunohistochemical Characterization of Cellular Infiltrates in Squamous Cell Carcinoma and Bowen's Disease Occurring in One Patient
Author(s) -
Terao Hiroshi,
Nakayama Juichiro,
Urabe Atsumichi,
Hori Yoshiaki
Publication year - 1992
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1992.tb03250.x
Subject(s) - cytotoxic t cell , immunohistochemistry , pathology , monoclonal antibody , bowen's disease , population , infiltration (hvac) , antibody , biology , carcinoma , immunology , medicine , basal cell , in vitro , biochemistry , physics , environmental health , thermodynamics
We investigated populations of the infiltrating cells in Bowen's disease (BD) and squamous cell carcinoma (SCC), both of which arose in the same patient, using the Avidin‐Biotin‐peroxidase complex method with eight monoclonal antibodies. T lymphocytes were most predominant among infiltrating cells; NK cells, B cells, and monocytes were rarely seen in either BD or SCC. Analysis of subsets of the infiltrating T lymphocytes revealed that the number of suppressor/cytotoxic (s/c) T cells was twice that of helper/inducer (h/i) T cells in BD, while the number of s/c T cells was lower than that of h/i T cells in SCC. The immunohistochemical results in the present case differed from those of predominant infiltration of h/i T cells and of s/c T cells in three other reports of BD and SCC. These results suggest that the population of the cellular infiltrates may be modulated by the nature of tumors and by the immuno‐competent state of the hosts.