Premium
Genetic Polymorphisms in the Fourth Component of Complement (C4) and in Properdin Factor B (BF) in Japanese Patients with Palmoplantar Pustulosis
Author(s) -
Torii Hideshi,
Nakagawa Hidemi,
Ishibashi Yasumasa,
Tokunaga Katsushi,
Juji Takeo
Publication year - 1992
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1992.tb03238.x
Subject(s) - palmoplantar pustulosis , properdin , complement factor b , pathogenesis , complement (music) , immunology , medicine , complement system , genetics , biology , gene , psoriasis , antibody , complementation , phenotype
Genetic polymorphisms in the fourth component of complement (C4) and in properdin factor B (BF) were investigated in 49 and 32 Japanese patients with palmoplantar pustulosis (PPP), respectively. C4B2 was significantly increased in frequency, whereas no significant deviations were detected in BF compared with the controls. These results may indicate that complement polymorphisms are involved in the pathogenesis of PPP.