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A Case of Intravascular Malignant Lymphomatosis (Angiotropic Large‐cell Lymphoma) Presenting Memory T Cell Phenotype and Its Expression of Adhesion Molecules
Author(s) -
Setoyama Mitsuru,
Mizoguchi Shimako,
Orikawa Tamiko,
Tashiro Masaaki
Publication year - 1992
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1992.tb03223.x
Subject(s) - pathology , medicine , peripheral blood mononuclear cell , hepatosplenomegaly , cell adhesion molecule , lymphoma , dermis , biology , immunology , biochemistry , disease , in vitro
A case of intravascular malignant lymphomatosis (angiotropic large cell lymphoma), T cell type was reported. The patient, a 59‐year‐old woman, had reddish or violaceous indurated macules scattered over the entire body surface. Neither lymphadenopathy nor hepatosplenomegaly was recognized. A chest Roentogenogram, whole body CT scan, and 67 Ga‐citrate scintigraphy yielded normal findings. Serum anti‐HTLV‐1 antibody was negative. Histopathologically, lesions showed intravascular large mononuclear cell proliferation associated with occasional fibrin thrombi formation in the dermis to subcutis. Immunohistochemically, the large mononuclear cell immuno‐phenotype had a memory T cell character. Also, both lymphocyte function‐associated antigen‐1s, CD11a and CD18, and intercellular adhesion molecule‐1 were demonstrated on the tumor cells and vascular walls in the lesions. To our knowledge, the present case is the fourth case of intravascular malignant lymphomatosis in the T cell lineage.