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Detection of Selenium in Generalized and Localized Argyria: Report of Four Cases with X‐ray Microanalysis
Author(s) -
Matsumura Tetsuri,
Kumakiri Masanobu,
Ohkawara Akira,
Himeno Hiroshi,
Numata Tsunemi,
Adachi Riri
Publication year - 1992
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1992.tb03186.x
Subject(s) - selenium , microanalysis , electron probe microanalysis , x ray , chemistry , deposition (geology) , pathology , electron microprobe , mineralogy , medicine , physics , biology , optics , organic chemistry , paleontology , sediment
Abstract Electron microscopic and X‐ray microanalytic studies were performed on four cases of argyria; one generalized and three localized. Deposition of electron dense granules was predominantly found on elastic fibers and around basal laminas of secretory portions of eccrine glands, although the amount of deposition was much less in the case of generalized argyria. In all four cases, X‐ray microanalysis revealed that the depositions consisted mainly of silver, selenium, and sulfur. The importance of selenium in the detoxification of heavy metals was discussed.