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Epidermal Keratinocytes of Bullous Pemphigoid Express Intercellular Adhesion Molecule‐1 (ICAM‐1)
Author(s) -
Karashima Tadashi,
Hachisuka Hiroshi,
Okubo Keiji,
Sasai Yoichiro
Publication year - 1992
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1992.tb03185.x
Subject(s) - bullous pemphigoid , icam 1 , keratinocyte , intercellular adhesion molecule 1 , pemphigus vulgaris , cell adhesion molecule , pemphigoid , lymphocyte function associated antigen 1 , intercellular adhesion molecule , antigen , pathology , chemistry , immunology , cell adhesion , biology , medicine , antibody , adhesion , in vitro , biochemistry , organic chemistry
Intercellular adhesion molecule‐1 (ICAM‐1) is the ligand for lymphocyte function associated antigen‐1 (LFA‐1), mediating the adhesion of lymphocytes to vascular endothelium. Keratinocytes are known to express ICAM‐1 in some inflammatory dermatoses. Using an indirect immunofluorescence method, we examined the patterns of ICAM‐1 and LFA‐1 staining in bullous pemphigoid (BP) lesions and compared them to pemphigus vulgaris (PV) cases. ICAM‐1 was expressed on the cell surface and in the cytoplasm of epidermal keratinocytes at the sites of erythematous and bullous lesions of BP. LFA‐1 molecules were expressed on T cells at the basement membrane zone. In addition, HLA‐DR‐positive keratinocytes were observed in the basal layer. ICAM‐1 was not, however, expressed on epidermal keratinocytes in uninvolved skin from BP patients, PV or normal control skin. It is known that ICAM‐1 is expressed on keratinocytes at the site of lymphoid infiltration in cutaneous dermatoses and that LFA‐1‐positive T cells can bind to interferon gamma‐induced ICAM‐1‐positive keratinocytes. Our results suggest that cellular immunity involving ICAM‐1 and LFA‐1 may play a part in the pathogenesis of bullous pemphigoid.