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Comparative Study of Ki‐67 Immunostaining and Nuclear DNA Content in Histiofibrous Tumors
Author(s) -
Ooe Mariko,
Nogita Toshitatsu,
Kawashima Makoto
Publication year - 1992
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1992.tb03173.x
Subject(s) - dermatofibrosarcoma protuberans , ki 67 , immunohistochemistry , monoclonal antibody , pathology , immunostaining , malignancy , flow cytometry , dermatofibroma , nuclear dna , differential diagnosis , proliferative index , proliferation index , antibody , biology , medicine , microbiology and biotechnology , immunology , biochemistry , gene , mitochondrial dna
A comparative assessment was made of dermatofibroma, dermatofibrosarcoma protuberans, and malignant fibrous histiocytoma. The study was comprised of an immunohistochemical investigation using the Ki‐67 monoclonal antibody and a quantitative analysis of cell nuclear DNA using flow cytometry. It was found that the index of Ki‐67 monoclonal antibody labeling, the histogram pattern, and DNA index correlated with clinical malignancy, suggesting the usefulness of these indices for differential diagnosis and evaluation of prognosis.