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Experimental Production of DLE Lesion with a Single Exposure to UVB (2.7 MEDs) Radiation
Author(s) -
Higuchi Dousei,
Ogura Yukari,
Watanabe Hideyoshi,
Takiuchi Iwao
Publication year - 1991
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1991.tb03131.x
Subject(s) - erythema , lesion , dermis , medicine , biopsy , irradiation , photosensitivity , dermatology , nuclear medicine , pathology , punch biopsy , materials science , physics , optoelectronics , nuclear physics
Abstract Keratotic erythematous lesions developed on the face, ears, neck, and upper back of a 38‐year‐old man. The patient had a history of photosensitivity to sunlight manifested by the development of new lesions. One week after an MED (2.7 mJ/cm 2 ) was determined using UV‐B light, persistent erythema with fine scales were observed at test sites irradiated over 72 mJ/cm 2 . These lasted for at least 2 months. A biopsy specimen obtained from the test site irradiated at 72 mJ/cm 2 showed liquefaction degeneration of the basal cell layer. Within the upper part of the dermis, perivascular and disseminated lymphocytic infiltrates were seen. However, when irradiated again under the same conditions 7 and 12 months after the initial phototest, no persistent erythema was observed.