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Late Phase Allergic Reaction to a CT Contrast Medium (Iotrolan)
Author(s) -
Kanzaki Tamotsu,
Sakagami Hiroshi
Publication year - 1991
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1991.tb03127.x
Subject(s) - spongiosis , dermis , infiltration (hvac) , erythema , intradermal injection , medicine , allergic reaction , contrast medium , pathology , edema , skin reaction , epidermis (zoology) , allergy , dermatology , anatomy , surgery , radiology , immunology , physics , thermodynamics
A 46‐year‐old male developed wide‐spread erythema and edema after intravenous injection of a CT contrast medium (iotrolan). The skin eruption appeared at 6 h, reached a maximum at 9 to 12 h, and faded within 36 h after injection. A challenge with an intradermal injection of the agent provoked the same reaction where the eruption had originally appeared, but had no effect on previously unaffected regions. Histopathologic examination revealed a perivascular infiltration of small round cells, and a few neutrophils, and eosinophils in the dermis and focal spongiosis in the epidermis. This is the first report of a late phase allergic skin reaction induced by iotrolan.