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Effects of Subminimal Inhibitory Concentrations of Erythromycin, Tetracycline, Clindamycin, and Minocycline on the Neutrophil Chemotactic Factor Production in Propionibacterium acnes Biotypes 1–5
Author(s) -
Akamatsu Hirohiko,
Nishijima Setsuko,
Takahashi Megumi,
Ushijima Tsutomu,
Asada Yasuo
Publication year - 1991
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1991.tb03077.x
Subject(s) - propionibacterium acnes , minocycline , microbiology and biotechnology , clindamycin , tetracycline , erythromycin , chemotaxis , minimum inhibitory concentration , propionibacterium , bacteria , biology , chemistry , antibiotics , biochemistry , receptor , genetics
Biotypes 1–5 Propionibacterium acnes (P. acnes) strains were grown in the presence of 1/10 minimal inhibitory concentrations (sub‐MIC) of erythromycin (EM), tetracycline (TC), clindamycin (CLDM), or minocycline (MINO) and their culture filtrates were assayed for human neutrophil chemotactic activity using Boyden chamber methods. The addition of sub‐MIC of MINO to the medium strongly suppressed the neutrophil chemotactic activity of the culture filtrates of P. acnes strains of all biotypes. In contrast, with sub‐MIC of EM, TC, or CLDM, the activity of the culture filtrates of P. acnes strains of biotypes 2 and 3 were suppressed but those of biotypes 1, 2, and 5 were not. These results indicate that sub‐MIC of MINO is capable of decreasing the inflammatory capacity of P. acnes strains of all biotypes.