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Epidermolysis Bullosa Acquisita in Identical Twins
Author(s) -
Murakami Shinji,
Shiraishi Satoshi,
Miki Yoshiharu
Publication year - 1991
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1991.tb03073.x
Subject(s) - epidermolysis bullosa acquisita , milia , scars , dermatology , medicine , erythema , basement membrane , epidermolysis bullosa , pathology , direct fluorescent antibody , autoantibody , antibody , immunology
Identical twin sisters developed generalized erythema and bullae on skin and mucous membranes at 18 and 19 years of age. Atrophic scars and milia were formed later. Indirect immunofluorescence (IF) study of the separated skin by incubation in 1.0M NaCl showed anti‐basement membrane zone (BMZ) antibodies bound to the dermal side. The HLA‐DR typing demonstrated DR2/DW11. Pulse therapy resulted in marked clinical improvement. This is the first report of epidermolysis bullosa acquisita (EBA) in identical twins and suggests the possibility that the disease may have a genetic component.