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Experimental Cutaneous Protothecosis in Mice: Epithelioid Cell Granuloma Formation
Author(s) -
Horiuchi Yasuhiro,
Tomizawa Nobuko,
Higuchi Iwao,
Nagasaka Kouichi
Publication year - 1991
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1991.tb03046.x
Subject(s) - dermis , epithelioid cell , pathology , stain , histiocyte , granuloma , staining , skin biopsy , biopsy , biology , periodic acid–schiff stain , subcutaneous tissue , immunohistochemistry , medicine
Prototheca wickerhamii , isolated from skin biopsy specimens of a patient with cutaneous protothecosis, were cultured in Sabouraud's medium and inoculated in the skin of 8 ICR albino mice and 3 BALB/c mice. Only in 3 ICR albino mice and 3 BALB/c mice were organisms found in skin tissue, as confirmed by identification of organisms by staining with periodic acid‐Schiff (PAS) stain and culture. Histologic findings from affected nodular skin lesions indicated epithelioid cell granuloma and histiocytic cell infiltrates in the dermis and subcutaneous tissue.