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ICAM‐1 and LFA‐1 Expressions in the Lesional Skin of Annular Erythema Associated with Sjögren Syndrome
Author(s) -
Katayama Ichiro,
Asai Toshiya,
Nishiyama Shigeo,
Nishioka Kiyoshi
Publication year - 1990
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1990.tb03019.x
Subject(s) - peripheral blood mononuclear cell , erythema , pathology , basal (medicine) , endothelial stem cell , medicine , biology , immunology , in vitro , endocrinology , biochemistry , insulin
ICAM‐1 and LFA‐1 expression was studied in the lesional skin of ten cases of annular erythema associated with Sjögren syndrome. Most of the infiltrating mononuclear cells around blood vessels expressed LFA‐1 in addition to its strong expression on vascular endothelial cells and focal expression on the epidermal basal cell layer in 3 cases. ICAM‐1 expression on vascular endothelial cells was similar to LFA‐1, although relatively focal and weak expression was observed on mononuclear cells. ICAM‐1 expression on keratinocytes was focal and limited to the basal cell layer in annular erythema. These findings suggest that strong expression of ICAM‐1 on endothelial cells but not keratinocytes and LFA‐1 on mononuclear cells might play some role in the induction of skin lesions in annular erythema associated with Sjögren syndrome.