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Infiltration of Melanoma Cells into the Type I Collagen Gel
Author(s) -
Kono Takeshi,
Furukawa Masayoshi,
Tanii Tsukasa,
Taniguchi Shoji,
Mizuno Nobuyuki,
Ishii Masamitsu,
Hamada Toshio
Publication year - 1990
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1990.tb01678.x
Subject(s) - infiltration (hvac) , melanoma , in vitro , cell culture , chemistry , cellular infiltration , pathology , biology , materials science , cancer research , immunology , medicine , composite material , biochemistry , inflammation , genetics
Melanoma cells were cultured on type I collagen gel, and the infiltration of those cells into the gel was observed. B16 murine melanoma cells initially adopted a spherical form on the gel, but they assumed a dendritic form after infiltration into the interior. The degree of infiltration increased very rapidly and was time‐dependent. No correlations between the growth rate or melanogenic activity and infiltrative potential were observed. When Syrian hamster and human melanoma cell lines were cultured, the degrees of infiltration varied. This culture system using collagen gel is considered to be a useful in vitro model of tumor cell invasion.