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Interleukin‐2 Production of T Cells in Atopic Dermatitis
Author(s) -
Morita Hideki,
Kihara Takako,
Miyamoto Michiko,
Yamagata Masaharu,
Sagami Seiichiro
Publication year - 1990
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1990.tb01659.x
Subject(s) - tranilast , atopic dermatitis , histamine , medicine , interleukin , lesion , immunology , cytokine , pathology
Patients with atopic dermatitis (AD) were treated with Tranilast. Interleukin‐2 (IL‐2) (production of T cells in vitro ) and blood histamine values, before and after Tranilast therapy, were measured, and the following results were obtained: 1) Compared with healthy controls, the IL‐2 producing ability of T cells in patients with AD was increased. 2) After Tranilast therapy, IL‐2 production of T cells in AD decreased in quantity to the control level. 3) Skin lesion severities of AD were correlated with the quantity of IL‐2 production of T cells. 4) Serum histamine levels were not significantly different between AD patients and healthy controls, before or after Tranilast therapy.