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In vitro Susceptibility of Mycobacterium marinum to Dihydromycoplanecin A and Ten Other Antimicrobial Agents
Author(s) -
Arai Hiroko,
Nakajima Hiroshi,
Kaminaga Yohichiro
Publication year - 1990
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1990.tb01658.x
Subject(s) - mycobacterium marinum , antimicrobial , microbiology and biotechnology , in vitro , mycobacterium , biology , bacteria , genetics
The in vitro susceptibilities of 16 Mycobacterium marinum strains to 11 antimicrobial agents were determined by the Dubos Tween albumin liquid dilution technique. The results (MICs) were: 0.19–0.39 µg/ml for dihydromycoplanecin A; 0.78–1.56 µg/ml for amikacin; 1.56–3.13 µg/ml for ofloxacin, norfloxacin and enoxacin; 1.56–6.25 µg/ml for minocycline; 1.56–25 µg/ml for sulfamethoxazole and sulfamethoxazole‐trimethoprim; 3.13–12.5 µg/ml for oxytetracycline; 25–200 µg/ml for trimethoprim; and 50–200 µg/ml for pipemidic acid. The most active drugs were dihydromycoplanecine A and amikacin. Also active were minocycline, oxytetracycline, sulfamethoxazole and sulfamethoxazole‐trimethoprim. Ofloxacin, norfloxacin and enoxacin demonstrated activity only at concentrations at or greater than those usually attained in serum. Pipemidic acid and trimethoprim were inactive.