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A Monocyte‐activation Inhibitory Factor Produced by Fibroblasts
Author(s) -
Baba Toru,
Naito Yukiko,
Uyeno Kenichi
Publication year - 1990
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1990.tb01657.x
Subject(s) - immunoadsorption , fibroblast , monoclonal antibody , inhibitory postsynaptic potential , monocyte , chemistry , interferon , cell culture , immunology , microbiology and biotechnology , cancer research , antibody , in vitro , biology , biochemistry , endocrinology , genetics
Culture media from human fibroblasts pretreated with culture media from activated normal human monocytes partially inhibited the activation of monocytes. Molecular weight of the major inhibitory factor in these culture media was very close to that of human fibroblast interferon. However, an immunoadsorption experiment using monoclonal antibody to human fibroblast interferon failed to adsorb this inhibitory factor.