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Cell‐mediated and Humoral Immunity in Leprosy in Children
Author(s) -
Sehgal Virendra N.,
Joginder,
Sharma Vinay K.,
Prakash S. Krishna
Publication year - 1990
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1990.tb01656.x
Subject(s) - immunology , humoral immunity , leprosy , immunity , antibody , medicine , cell mediated immunity , cellular immunity , immune system , sensitization
Cell‐mediated and humoral immunity were studied in 25 children between 0 and 14 years with leprosy. Cell‐mediated immunity was studied in vivo by lepromin and epicutaneous sensitization with dinitrochlorobenzene (DNCB) and T‐lymphocytes and their subpopulations (T 4 and T 8 ) in the peripheral blood. Humoral immunity was evaluated by B‐lymphocyte count and immunoglobulins (IgG, IgM and IgA). Along with complement, component C3 was also measured in the serum. Lepromin (Mitsuda) and DNCB responses were significantly poor in mid‐borderline (BB) leprosy. The hematological profile, including T‐lymphocytes, their subpopulations, B‐lymphocytes, serum immunoglobulins, and C3, were found to be normal in all forms of leprosy. The relatively short duration of disease and the low bacterial load may explain these findings.