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The Relationship between Solar Keratoses and Squamous Cell Carcinomas among Japanese
Author(s) -
Takemiya Masataka,
Ohtsuka Hisashi,
Miki Yoshiharu
Publication year - 1990
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1990.tb01654.x
Subject(s) - medicine , dermatology , xeroderma pigmentosum , basal cell , scars , actinic keratoses , sun exposure , lymph , pathology , dna , genetics , dna damage , biology
Between 1976 and 1988, 135 patients with solar keratosis (SK) and 53 patients with squamous cell carcinoma (SCC) on the sun‐exposed skin, but without apparent preceding diseases such as burn scars, chronic radiodermatitis, chronic arsenic poisoning, or xeroderma pigmentosum, were encountered. Sixteen of the SCC patients also had SK on other areas of sun‐exposed skin. There were 31 SCC patients also showing SK (SK‐SCC) and 22 SCC not showing SK (DN‐SCC) within the same histologic sections. The mean ages of the patients with SK‐SCC and with DN‐SCC were similar. Metastases to regional lymph nodes were observed in 5 SK‐SCC patients, of whom 3 died of the disease, and in 5 DN‐SCC patients, of whom 4 died of the disease. The five‐year post‐operative survival rates were 70% in SK‐SCC and 74% in DN‐SCC; the ten‐year post‐operative survival rates were 70% in SK‐SCC and 44% in DN‐SCC.