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Antiproliferative Effect of Hyperthermia and ACNU on Cultured Human Malignant Melanoma Cells
Author(s) -
Someya Tohru,
Nogita Toshitatsu,
Yamada Kiyoshi,
Tsuchida Tetsuya,
Watanabe Ryoji,
Otsuka Fujio
Publication year - 1990
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1990.tb01645.x
Subject(s) - hyperthermia , in vitro , in vivo , melanoma , cancer research , hydrochloride , chemistry , tumor cells , pharmacology , medicine , biology , biochemistry , genetics
Human malignant melanoma cultured cells were treated either with ACNU (1‐(4‐amino‐2‐methyl‐5‐pyrimidinyl)methyl‐3‐(2‐chlorethyl)‐3‐nitrosourea hydrochloride), hyperthermia, or the combination of ACNU and hyperthermia. The combination treatment inhibited the cell growth to a slightly synergistic degree compared to the respective single treatments. The present in vitro experimental results support in part the finding of our previous report that the combination treatment with ACNU and hyperthermia have a significantly synergistic antitumor effect to human melanoma transplanted to nude mice. However, the synergistic effect was much less intense in the present in vitro experiment. The difference may have resulted from the environmental differences between in vitro and in vivo experimental systems.