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Tiopronin‐induced Lichenoid Eruption in a Patient with Liver Disease and Positive Patch Test Reaction to Drugs with Sulfhydryl Group
Author(s) -
Kurumaji Yuko,
Miyazaki Kazuhiro
Publication year - 1990
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1990.tb01621.x
Subject(s) - tiopronin , provocation test , medicine , patch test , dermatology , drug , etiology , penicillamine , gastroenterology , pharmacology , pathology , immunology , allergy , alternative medicine
A 62‐year‐old woman suffering from liver cirrhosis developed lichenoid eruptions after 2 years of treatment with tiopronin. The lesions healed spontaneously within a month after withdrawal of the drug. In patch testing, the patient reacted positively, not only to tiopronin, but also to captopril and D‐penicillamine, neither of which she had ever taken before. The provocation test was positive only to tiopronin, and its histological findings revealed lichenoid reaction. It is suggested that the sulfhydryl group may play a role in the etiology of tiopronin‐induced lichenoid drug eruption.